This repository provides the canagliflozin physiologically based pharmacokinetics (PBPK) model.
The model is distributed as SBML available from canagliflozin_body_flat.xml with
corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/canagliflozin-model/main/models/canagliflozin_body_flat.xml and equations from canagliflozin_body_flat.md.
The COMBINE archive is available from canagliflozin_model.omex.
The liver submodel is available from canagliflozin_liver.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/canagliflozin-model/main/models/canagliflozin_liver.xml and equations from canagliflozin_liver.md.
The kidney submodel is available from canagliflozin_kidney.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/canagliflozin-model/main/models/canagliflozin_kidney.xml and equations from canagliflozin_kidney.md.
The intestine submodel is available from canagliflozin_intestine.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/canagliflozin-model/main/models/canagliflozin_intestine.xml and equations from canagliflozin_intestine.md.
The whole-body submodel is available from canagliflozin_body.xml with corresponding SBML4humans report at
https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/canagliflozin-model/main/models/canagliflozin_body.xml and equations from canagliflozin_body.md.
Tereshchuk, V., & König, M. (2025). Physiologically based pharmacokinetic (PBPK) model of canagliflozin.
Zenodo. https://doi.org/10.5281/zenodo.13759839
- Source Code: MIT
- Documentation: CC BY-SA 4.0
- Models: CC BY-SA 4.0
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).
© 2023-2025 Vera Tereshchuk and Matthias König, Systems Medicine of the Liver