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# Topaz
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A pipeline for particle detection in cryo-electron microscopy images using convolutional neural networks trained from positive and unlabeled examples. Topaz also includes methods for micrograph and tomogram denoising using deep denoising models.
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**Check out our [Discussion](https://github.com/tbepler/topaz/discussions) section for general help, suggestions, and tips on using Topaz.**
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## New in v0.2.5
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- Added Relion integration scripts
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- Topaz extract can now write particle coordinates to one file per input micrograph
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# Bugs & Suggestions
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Please report any bugs, problems, suggestions, or requests as a [Github issue](https://github.com/tbepler/topaz/issues).
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Please report bugs and make specific feature requests and suggestions for improvements as a [Github issue](https://github.com/tbepler/topaz/issues).
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For general help, questions, suggestions, tips, and installation/setup assistance, please take a look at our new [Discussion](https://github.com/tbepler/topaz/discussions) section.

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