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MAM20019r has no synthesis routes #992

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liamkelley93 opened this issue Apr 1, 2025 · 0 comments
Open

MAM20019r has no synthesis routes #992

liamkelley93 opened this issue Apr 1, 2025 · 0 comments
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@liamkelley93
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The ER-localized version of FMNH2, MAM20019r, participates in 5 reactions:

  • MAR20021
  • MAR20023
  • MAR20025
  • MAR20027
  • MAR20029

In each case, FMNH2 acts as a reactant in a non-reversible reaction. As a result, there is no synthesis route for the metabolites, and all of these reactions must have a flux of 0 under steady-state. I don't know whether this should be addressed by the reactions having reversibility, or whether FMNH2 transport into the ER is missing, or what.

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