Duplicate Palmitoyl-CoA Beta-Oxidation Reactions

[Devlin-Moyer]

Current behavior:

There appear to be a few duplicate reactions representing the beta-oxidation of palmitoyl-CoA:

ID	Reaction	GPR
MAR03121	FAD [m] + palmitoyl-CoA [m] --> (2E)-hexadecenoyl-CoA [m] + FADH2 [m]	ACADVL or ACADL or ACADM or ACAD9
MAR03122	(2E)-hexadecenoyl-CoA [m] + H2O [m] --> (S)-3-hydroxyhexadecanoyl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03123	(S)-3-hydroxyhexadecanoyl-CoA [m] + NAD+ [m] --> 3-oxopalmitoyl-CoA [m] + H+ [m] + NADH [m]	HSD17B10 and HADHA and HADH
MAR03125	3-oxopalmitoyl-CoA [m] + CoA [m] --> acetyl-CoA [m] + myristoyl-CoA [m]	HADHA and HADHB and ACAA2
MAR03128	FAD [m] + myristoyl-CoA [m] --> (2E)-tetradecenoyl-CoA [m] + FADH2 [m]	ACADVL or ACOX3 or ACADL or ACADM or ACOX1 or ACAD9
MAR03129	(2E)-tetradecenoyl-CoA [m] + H2O [m] --> (S)-3-hydroxytetradecanoyl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03130	(S)-3-hydroxytetradecanoyl-CoA [m] + NAD+ [m] --> 3-oxotetradecanoyl-CoA [m] + H+ [m] + NADH [m]	HSD17B10 and HADHA and HADH
MAR03132	3-oxotetradecanoyl-CoA [m] + CoA [m] --> acetyl-CoA [m] + lauroyl-CoA [m]	HADHA and HADHB and ACAA2
MAR03135	FAD [m] + lauroyl-CoA [m] --> (2E)-dodecenoyl-CoA [m] + FADH2 [m]	ACADVL or ACADL or ACADM or ACAD9
MAR03136	(2E)-dodecenoyl-CoA [m] + H2O [m] --> (S)-3-hydroxydodecanoyl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03137	(S)-3-hydroxydodecanoyl-CoA [m] + NAD+ [m] --> 3-oxododecanoyl-CoA [m] + H+ [m] + NADH [m]	HSD17B10 and HADHA and HADH
MAR03139	3-oxododecanoyl-CoA [m] + CoA [m] --> acetyl-CoA [m] + decanoyl-CoA [m]	HADHA and HADHB and ACAA2
MAR03142	FAD [m] + decanoyl-CoA [m] ⇒ (2E)-decenoyl-CoA [m] + FADH2 [m]	ACADM or ACAD9
MAR03143	(2E)-decenoyl-CoA [m] + H2O [m] ⇒ (S)-hydroxydecanoyl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03144	(S)-hydroxydecanoyl-CoA [m] + NAD+ [m] ⇒ 3-oxodecanoyl-CoA [m] + H+ [m] + NADH [m]	HSD17B10 and HADHA and HADH
MAR03146	3-oxodecanoyl-CoA [m] + CoA [m] ⇒ acetyl-CoA [m] + octanoyl-CoA [m]	HADHA and HADHB and ACAA2
MAR03150	(2E)-octenoyl-CoA [m] + H2O [m] ⇒ (S)-hydroxyoctanoyl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03151	(S)-hydroxyoctanoyl-CoA [m] + NAD+ [m] ⇒ 3-oxooctanoyl-CoA [m] + H+ [m] + NADH [m]	HSD17B10 and HADHA and HADH
MAR03153	3-oxooctanoyl-CoA [m] + CoA [m] ⇒ acetyl-CoA [m] + hexanoyl-CoA [m]	HADHA and HADHB and ACAA2
MAR03156	FAD [m] + hexanoyl-CoA [m] ⇒ (2E)-hexenoyl-CoA [m] + FADH2 [m]	ACADSB
MAR03157	(2E)-hexenoyl-CoA [m] + H2O [m] ⇒ (S)-hydroxyhexanoyl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03158	(S)-hydroxyhexanoyl-CoA [m] + NAD+ [m] ⇒ 3-oxohexanoyl-CoA [m] + H+ [m] + NADH [m]	HSD17B10 and HADHA and HADH
MAR03160	3-oxohexanoyl-CoA [m] + CoA [m] ⇒ acetyl-CoA [m] + butyryl-CoA [m]	HADHA and HADHB and ACAA2
MAR03163	FAD [m] + butyryl-CoA [m] ⇒ FADH2 [m] + crotonyl-CoA [m]	ACADM or ACADS or ACADSB or ACAD8 or ACAD9 or ACAD11
MAR03164	H2O [m] + crotonyl-CoA [m] ⇒ (S)-3-hydroxybutyryl-CoA [m]	HADHA and EHHADH and ECHS1
MAR03166	(S)-3-hydroxybutyryl-CoA [m] + NAD+ [m] ⇒ H+ [m] + NADH [m] + acetoacetyl-CoA [m]	HSD17B10 and HADHA and HADH
MAR03885	CoA [m] + acetoacetyl-CoA [m] ⇔ 2 acetyl-CoA [m]	ACAT1
MAR05325	CoA [m] + FAD [m] + H2O [m] + NAD+ [m] + palmitoyl-CoA [m] --> acetyl-CoA [m] + FADH2 [m] + H+ [m] + myristoyl-CoA [m] + NADH [m]	ACADVL and HADHA and HADHB
MAR00764	(2E)-hexadecenoyl-CoA [m] + 4 CoA [m] + 3 FAD [m] + 4 H2O [m] + 4 NAD+ [m] --> 4 acetyl-CoA [m] + 3 FADH2 [m] + 4 H+ [m] + 4 NADH [m] + octanoyl-CoA [m]	ACADM or ACADS
MAR00757	4 CoA [m] + 4 FAD [m] + 4 H2O [m] + 4 NAD+ [m] + palmitoyl-CoA [m] --> 4 acetyl-CoA [m] + 4 FADH2 [m] + 4 H+ [m] + 4 NADH [m] + octanoyl-CoA [m]	ACADM or ACADS
MAR00756	7 CoA [m] + 7 FAD [m] + 7 H2O [m] + 7 NAD+ [m] + palmitoyl-CoA [m] --> 8 acetyl-CoA [m] + 7 FADH2 [m] + 7 H+ [m] + 7 NADH [m]	ACADM or ACADS

Proposed changes:

• Remove MAR05325 for being a duplicate of MAR03121 + MAR03122 + MAR03123 + MAR03125
• Remove MAR00764 for being a duplicate of MAR03122 + MAR03123 + MAR03125 + MAR03128 + MAR03129 + MAR03130 + MAR03132 +MAR03135 + MAR03136 + MAR03137 + MAR03139 + MAR03142 + MAR03143 + MAR03144 + MAR03146
• Remove MAR00757 for being a duplicate of MAR03121 + MAR03122 + MAR03123 + MAR03125 + MAR03128 + MAR03129 + MAR03130 + MAR03132 +MAR03135 + MAR03136 + MAR03137 + MAR03139 + MAR03142 + MAR03143 + MAR03144 + MAR03146
• Remove MAR00756 for being a duplicate of MAR03121 + MAR03122 + MAR03123 + MAR03125 + MAR03128 + MAR03129 + MAR03130 + MAR03132 + MAR03135 + MAR03136 + MAR03137 + MAR03139 + MAR03142 + MAR03143 + MAR03144 + MAR03146 + MAR03149 + MAR03150 + MAR03151 + MAR03153 + MAR03156 + MAR03157 + MAR03158 + MAR03160 + MAR03163 + MAR03164 + MAR03166 + MAR03885