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Clinvar vcf processing errors #336

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tkmamidi opened this issue Apr 18, 2025 · 0 comments
Open

Clinvar vcf processing errors #336

tkmamidi opened this issue Apr 18, 2025 · 0 comments

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@tkmamidi
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Describe the bug
I'm trying to run vcf downloaded from clinvar just to test how the normalization would handle and it is erroring out a lot of variants either by syntax error or by index.

To Reproduce
Steps to reproduce the behavior:

  1. Download the latest clinvar vcf file
  2. Run opencravat without any annotation, just the base module - oc run clinvar.vcf.gz -l hg38
  3. Observe the command line errors popping up

Expected behavior
It should process all variants from the vcf with minimal errors.

Screenshots

Image

I see one that should error out but the top one seems fine?

Desktop (please complete the following information):

  • OS: iOS
  • Using latest version of open-cravat
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